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AssigneeCalm Water Therapeutics LLC
InventorsEugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
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The invention contemplates a copolymer which is a graft or block copolymer useful to change the ocular surface temperature and other characteristics of biological or contact lens surfaces. Methods for use of these formulations and coatings to increase the temperature of the skin, mucous membranes, eye or eyelids will help treat many conditions including blepharitis and non-healing ulcers. Methods to decrease evaporation, improve wettability and stabilize the tear film, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to improve contact lens tolerability, are provided.
A method to increase the surface temperature on the external surface of a treated contact lens that is on the eye of a subject as compared to an untreated contact lens that is on the eye of a subject, comprising contacting the eye of said subject with said treated contact lens, wherein said treated contact lens is in association with a pharmaceutical composition comprising a copolymer having a positively charged moiety and a hydrophilic moiety, wherein said contacting is effected in an amount and for a duration so as to increase the surface temperature on the external surface of said treated contact lens that is on the eye of said subject as compared to an untreated contact lens that is on the eye of said subject, thereby increasing the surface temperature on the external surface of a treated contact lens that is on the eye of a subject as compared to an untreated contact lens that is on the eye of a subject.
A method to treat blepharitis in a patient by increasing the temperature of the affected contact-lens wearing eye by treating said contact lens with a copolymer having a positively charged moiety and a hydrophilic moiety, wherein said contacting is effected in an amount and for a duration so as to increase the surface temperature on the external surface of said treated contact lens that is on the eye of said patient as compared to an untreated contact lens that is on the eye of said patient, thereby treating blepharitis in said patient.
A method to treat a chalazion in a patient by increasing the temperature of the affected contact-lens wearing eye by treating said contact lens with a copolymer having a positively charged moiety and a hydrophilic moiety, wherein said contacting is effected in an amount and for a duration so as to increase the surface temperature on the external surface of said treated contact lens that is on the eye of said patient as compared to an untreated contact lens that is on the eye of said patient, thereby treating chalazion in said patient.
A method to treat dry eye syndrome in a patient by increasing the temperature of the affected contact-lens wearing eye by treating said contact lens with a copolymer having a positively charged moiety and a hydrophilic moiety, wherein said contacting is effected in an amount and for a duration so as to increase the surface temperature on the external surface of said treated contact lens that is on the eye of said patient as compared to an untreated contact lens that is on the eye of said patient, thereby treating dry eye syndrome in said patient.
Dependencies are inferred from the claim text.