Inhibition of mammalian target of rapamycin
AssigneesBoard of Regents, The University of Texas System, Southwest Research Institute
InventorsZelton Dave Sharp, John R. Strong, Veronica Galvan, Salvatore Oddo, Herbert G. Wheeler
Life of this patent
Estimating the term…
Abstract
Disclosed are microcapsules that include an inhibitor of the mammalian target of rapamycin (mTOR) within the microcapsules, and pharmaceutical compositions and kits that include the microcapsules. Also disclosed are methods for treating or preventing an age-related disease, condition, or disorder in a subject that involve administering to a subject a pharmaceutically effective amount of microcapsules that includes an inhibitor of mTOR within the microcapsules.
Claims26
A microcapsule pharmaceutical preparation, comprising:
- a) a core component comprising an inhibitor of mammalian target of rapamycin (mTOR) comprising rapamycin or an analog of rapamycin;
- and
- b) a solid excipient matrix comprising an enteric coating material, wherein said inhibitor of mTOR is microencapsulated by said enteric coating material, and wherein said enteric coating material remains intact at a pH level of about or less than 7.
A kit comprising a first sealed container comprising a microcapsule pharmaceutical preparation, wherein the microcapsule is comprised of a core component comprising an inhibitor of mammalian target of rapamycin (mTOR), wherein said inhibitor of mTOR is rapamycin or a rapamycin analog, and wherein said core component is microencapsulated and encased in an enteric coating material.
Dependencies are inferred from the claim text.