Loading patent…
AssigneesInserm (Institute National De Ka Santé Et De La Recherche MéDicale), Centre Hospitalier RéGional Universitare De Limoges, Universite De Limoges
InventorsSouleiman EL BALKHI, Franck SAINT MARCOUX, Jean-Baptiste WOILLARD
Estimating the term…
Most chronic liver diseases are notoriously asymptomatic, until cirrhosis with clinical decompensation occurs. The use of early diagnosis strategies is vital to maintain patients in a symptom-free state and to delay decompensation, and thus improve the outcome. Albumin (HAS) undergoes several post-translational modifications in hepatocytes but clinical relevance of some of these modifications has been recently investigated in advanced liver diseases. Now, the inventors demonstrate that the binding capacities of some ligands, measured by inductively coupled plasma mass spectrometry (ICP-MS), are significantly different between cirrhotic patients and patients with no liver dysfunctions. The decreased binding capacities in cirrhotic patients were paralleled by the presence of significantly higher HSA isoforms Animal experimentations were also conducted to explore the precocity of HSA modifications in the course of chronic liver dysfunction. This allow the inventors to assume that the most important modifications of albumin structure due to liver dysfunction could be revealed by measuring the unbound fraction of specific ligands spiked in serum.
A method for determining whether a subject suffers or is at risk of suffering from a liver dysfunction comprising measuring a plurality of ligand binding capacities to serum albumin wherein said measured plurality of ligand binding capacities indicates whether the subject suffers or is at risk of suffering from a liver dysfunction.
A method of determining whether a subject suffering from a liver disease is responding to a therapy, comprising
A method of evaluating whether a drug causes liver injury in a subject during a preclinical or clinical study, comprising
A method of determining whether a subject suffers from a liver disease and treating the subject, comprising
Dependencies are inferred from the claim text.