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AssigneeBio-Rad Laboratories, Inc.
InventorsQIAN GAO, RAVI KAUL, SHUXIA ZHOU, ROGER P. WALKER
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The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.
A substrate comprising a population of particles or beads comprising two or more separate subpopulations of particles or beads, each subpopulation of particles or beads being distinguishable by a specific detectable parameter and each subpopulation of beads comprising a distinct SARS-CoV-2 spike protein variant or fragment thereof immobilized thereon and, optionally, a further subpopulation of beads comprising a SARS-CoV-2 spike protein or fragment thereof immobilized thereon.
Dependencies are inferred from the claim text.