Vesicle-coated fibers and methods of making and using
AssigneeThe Regents of the University of California
InventorsAnand Bala Subramaniam, Joseph Pazzi, Vaishnavi Girish
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Abstract
Methods and compositions for rapid and efficient assembly of fibers coated with lamellar vesicles are provided. Cosmetic and therapeutic uses of vesicle-coated fibers are also provided.
Claims39
A method for making a vesicle-coated substrate, the method comprising:
- (a) dispersing an amphiphilic molecule in a solvent;
- (b) contacting the dispersed amphiphilic molecule of (a) with a fibrous substrate;
- (c) removing the solvent;
- and
- (d) incubating the amphiphile-coated substrate in a first aqueous solution.
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A method for preparing an amphiphile-coated substrate, the method comprising:
- (a) dispersing an amphiphilic molecule in a solvent;
- (b) contacting the dispersed amphiphilic molecule of (a) with the substrate;
- (c) removing the solvent;
- and
- (d) incubating the amphiphile-coated substrate in a first aqueous solution containing a dissolved osmolyte, wherein the osmolarity of the first solution prevents vesiculation.
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A method for forming vesicles on a substrate, wherein the vesicles comprise a hydrophilic compound in the vesicle lumen, the method comprising:
- (a) depositing a solution of the hydrophilic compound on the substrate;
- (b) allowing the solution to dry onto the substrate;
- (c) applying a solution of an amphiphilic molecule to the substrate;
- and
- (d) placing the substrate of step (c) in an aqueous solution.
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Dependencies are inferred from the claim text.