Methods of diagnosing a disease state

A method of diagnosing a disease state of a human subject, said method comprising the steps of:

• a) measuring the level of expression of at least one small non-coding RNA comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs:
• 1 to 79, in a sample from the subject, wherein the sample comprises extracellular vesicles;
• and
• b) comparing the level of expression of the at least one small non-coding RNA to a reference level of expression of the at least one small non-coding RNA, wherein an increased or decreased level of expression of the at least one small non-coding RNA compared to the reference level is indicative of a disease state or a stage of development of a disease state.