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US 2022/0017894 A1Published application
Compositions and methods for in vivo screening of therapeutics
AssigneeGordian Biotechnology, Inc.
InventorsMartin Borch Jensen, Francisco LePort
Life of this patent
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Abstract
Provided herein are compositions and methods of use thereof for screening a plurality of uniquely identifiable therapeutic moiety in vivo by identifying one or more reporters indicative of a cell state.
Claims22
A method for identifying a candidate therapeutic moiety comprising:
- administering to an animal or an organoid a library of expression cassettes comprising:
- a plurality of nucleic acid sequences, each encoding a different therapeutic moiety operably linked to a therapeutic moiety barcode;
- and
- a plurality of nucleic acid sequences encoding one or more reporters that collectively, when expressed in a cell, are indicative of a cell state or a likelihood of a cell state of the cell;
- and
- identifying a candidate therapeutic moiety that results in a change in a cell state or a likelihood of a cell state of a cell of the animal or the organoid.
3 more elements
An animal or an organoid comprising a plurality of cells, each of the plurality of cells expressing:
- a different therapeutic moiety operably linked to a therapeutic moiety barcode;
- and
- one or more reporters that collectively, when expressed in a cell, are indicative of a cell state or a likelihood of a cell state of the cell.
Dependencies are inferred from the claim text.