Repair of uv-induced dna lesions
AssigneeAsterion Therapeutics Bvba
InventorJeroen HOFENK
Life of this patent
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Abstract
A composition comprising a recombinant enzyme that comprises a fusion of: a cyclobutane pyrimidine dimer photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 1, a pyrimidine(6-4)pyrimidone photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 2, and a skin penetrating peptide.
Claims16
-15. (canceled)
A composition comprising a recombinant enzyme that comprises a fusion of a cyclobutane pyrimidine dimer photolyase, a pyrimidine(6-4)pyrimidone photolyase and a skin penetrating peptide,
- wherein said cyclobutane pyrimidine dimer photolyase corresponds to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 1,
- wherein said pyrimidine(6-4)pyrimidone photolyase corresponds to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 2.
A nucleic acid molecule comprising a first fragment having at least 85% sequence identity to SEQ ID NO:
- 1, coding for cyclobutane pyrimidine dimer photolyase, a second fragment having at least 85% sequence identity to SEQ ID NO:
- 2, coding for a pyrimidine(6-4)pyrimidone photolyase and a third fragment that encodes a skin penetrating peptide.
Dependencies are inferred from the claim text.