Bispecific binding molecules binding to VEGF and Ang2
AssigneeBoehringer Ingelheim International GmbH
InventorsAndreas GSCHWIND, Rene Georg OTT, Joachim BOUCNEAU, Marie-Ange BUYSE, Erik DEPLA
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Abstract
Bispecifc binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2-mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
Claims40
A bispecific binding molecule comprising at least one VEGF-binding component, at least one Ang2-binding component and at least one serum albumin binding component, wherein said Ang2-binding component binds to Ang2 with a potency at least 5,000 times higher than to Ang1 or to Ang4.
An Ang2-binding VHH with an amino acid sequence selected from acid sequences shown in SEQ ID NOs:
- 214, 215, 216, 217, 218, 219, 220, 221, 222, or 223.
Dependencies are inferred from the claim text.