Cyclic peroxides as prodrugs for selective delivery of agents

A compound having the formula:

• wherein
• L2, L3, L4, L5, L6, L7, L8, L9, L11, and L12 are independently a bond, —N(R17)-L13-L14-, —N(R17)C(O)O-L13-L14-, —O-L13-L14-, —S-L13-L14-, —OC(O)—L13-L14-, —OC(O)N(R17)-L13-L14-, —OC(O)O-L13-L14-, —OSO2-L13-L14-, —C(O)N(R17)-L13-L14-, —N(R17)C(O)-L13-L14-, —S(O)2N(R17)-L13-L14-, —N(R17)S(O)2-L13-L14-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• L10 is —N(-L11-R11— or —C((-L11-R11)(-L12-R12))-;
• each L13 and L14 are independently a bond, —N(R17)—, —N(R17)C(O)O—, —O—, —S—, —OC(O)—, —OC(O)N(R17)—, —OC(O)O—, —OSO2—, —C(O)N(R17)—, —N(R17)C(O)—, —S(O)2N(R17)—, —N(R17)S(O)2—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are independently hydrogen, oxo, halogen, —CX3, —CN, —SO2Cl, —SOvR16, —SOvNR13R14, —NHNH2, —ONR13R14, —NHC═(O)NHNH2, —NHC═(O)NR13R14, —N(O)m, —NR13R14, —C(O)R15, —C(O)—OR15, —C(O)NR13R14, —OR16, —NR13SO2R16, —NR13C═(O)R15, —NR13C(O)—OR15, —NR13OR15, —OCX3, —OCHX2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a protein moiety, a detectable moiety, or a drug moiety;
• R5 and R11 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 and R11 substituents may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 and R3, R4 and R5, R6 and R7, R8 and R9, or R11 and R12 may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each R13, R14, R15, R16, and R17 are independently hydrogen, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O) NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 and R14 substituents bonded to the same atom may be joined to form a substituted or unsubstitued heterocycloalkyl or substituted or unsubstituted heteroaryl;
• R18 and R19 are independently hydrogen, halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, —NHC═(O)NH2, —NHSO2H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCHF2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, a protein moiety, detectable moiety, siderophore moiety, or a drug moiety;
• R18 and R19 may be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, protein moiety, detectable moiety, or drug moiety;
• m and v are independently 1 or 2;
• n is an integer from 0 to 2;
• Y is —O—, —S—, —OO—, —CH2O—, or —OCH2—;
• and
• X is independently —Cl, —Br, —I, or —F.