Novel l-proline sulfonamide derivatives comprising pyrazolo[4,3- e]tetrazolo[4,5-b][1,2,4]triazine system, method of manufacturing thereof, uses thereof and pharmaceutical composition comprising the same

A method of manufacturing a sulfonamide derivative of 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine of a general Formula 1, wherein R is proline methyl ester or 4-hydroxy-L-proline methyl ester, characterized in that 1-(para-chlorosulphonylphenyl)-3-methyl-5-methylsulphonyl-1H-pyrazolo[4.3-e][1.2.4]triazine is subjected to reaction with L-proline methyl ester hydrochloride or 4-hydroxy-Z-proline methyl ester hydrochloride in anhydrous acetonitrile in the presence of sodium carbonate thus obtaining a suitable sulfonamide derivative with methylsulfone group at position 5 of 1H-pyrazolo[4,3-e][1,2,4]triazine system, which derivative is subsequently subjected to reaction with sodium azide in anhydrous ethanol.

-14. (canceled)