Lox inhibitors

A compound having the structure of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• m and n are each independently selected from 1, 2, 3 or 4, and where two ring carbon atoms of the cyclic diamine moiety of formula
• may be
• (i) optionally linked by a bond,
• (ii) optionally bridged by —(CR9R10)o—, where R9 and R10 are at each occurrence independently selected from H and unsubstituted C1-4 alkyl and o is 1, 2, 3 or 4;
• or
• (iii) optionally linked by a spiro carbon atom;
• and
• each ring carbon atom of said cyclic diamine moiety may be optionally substituted by one or two substituents independently selected from C1-C6 alkyl, C1-C6 alkyl substituted with —OR2a, or C1-C6 alkyl substituted with —NR2aR2b;
• L1 and L2 are each independently selected from a bond, —O—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NR3—, —NR3C(O)—, —NR3—, —SO2NR3—, —NR3SO2—, —S—, —SO2—, —SO2O—, —OSO2—, —NR3SO2NR4—, —NR3C(O)NR4—, —NR3C(O)O— or —OC(O)NR3—;
• L3 is selected from a bond, C1-C4 alkylene, C2-C4 alkenylene or C2-C4 alkynylene, where
• any alkylene, alkenylene or alkynylene in L3 may be optionally substituted by one or two substituents independently selected from halo, cyano, oxo, hydroxy, carboxy, R2, —OR2, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)NR6R7, —NR6C(O)R7, —NR6R7, —SO2NR6R7, —NR6SO2R7, —SR6, —SO2R6, —SO2OR6, —OSO2R6, —NR6SO2NR7R8, —NR6C(O)NR7R8, —NR6C(O)OR7 or —OC(O)NR6R7;
• X, Y and Z are each independently selected from a bond or a 3- to 12-membered ring system, including 0, 1, 2 or 3 heteroatoms selected from N, O or S in the ring system, where
• any ring system in X, Y and Z may be optionally substituted by one or more substituents independently selected from halo, cyano, oxo, hydroxy, carboxy, R2, —OR2, —C(O)R2, —C(O)OR2,—OC(O)R2, —C(O)NR4R5, —NR3C(O)R4, —NR4R5, —SO2NR4R5, —NR3SO2R4, —SR3, —SO2R3, —SO2OR3, —OSO2R3, —NR3SO2NR4R5, —R3C(O)NR4R5, —NR3C(O)OR4 or —OC(O)NR4R5;
• R1 is selected from hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or a 3- to 12-membered ring system (e.g. cycloalkyl, heterocyclyl, aryl or heteroaryl), including 0, 1, 2 or 3 heteroatoms selected from N, O or S in the ring system, where
• any alkyl, alkenyl or alkynyl in R1 may be optionally substituted by one, two or three substituents independently selected from halo, cyano, amino, oxo, hydroxy, carboxy, R2, —OR2, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)NR4R5, —NR3C(O)R4, —NR4R5, —SO2NR4R5, —NR3SO2R4, —SR3, —SO2R3, —SO2OR3, —OSO2R3, —NR3SO2NR4R5, —NR3C(O)NR4R5, —NR3C(O)OR4 or —OC(O)NR4R5;
• and
• any ring system in R1 may be optionally substituted by one or more substituents independently selected from halo, cyano, oxo, hydroxy, carboxy, R2, —OR2, —C(O)R2, —C(O)OR2,—OC(O)R2, —C(O)NR4R5, —NR3C(O)R4, —NR4R5, —SO2NR4R5, —NR3SO2R4, —SR3, —SO2R3, —SO2OR3, —OSO2R3, —NR3SO2NR4R5,—NR3C(O)NR4R5, —NR3C(O)OR4 or —OC(O)NR4R5;
• R2 is at each occurrence independently selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, where
• any alkyl, alkenyl, alkynyl or cycloalkyl in R2 may be optionally substituted by one, two or three substituents independently selected from halo, cyano, oxo, R2a, —OR2a, —C(O)R2a, —C(O)OR2a, —OC(O)R2a, —C(O)NR2aR2b, —NR2aC(O)R2b, —NR2aR2b, —SO2NR2aR2b, —NR2aSO2R2b, —SR2a, —SO2R2a, —SO2OR2a, —OSO2R2a, —NR2aSO2NR2bR2, —NR2aC(O)NR2bR2c, —NR2aC(O)OR2b or —OC(O)NR2aR2b;
• R2a, R2b and R2c are at each occurrence independently selected from hydrogen or unsubstituted C1-C4 alkyl;
• R3, R4 and R5 are at each occurrence independently selected from hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, where
• any alkyl or cycloalkyl in R3, R4 and R5 may be optionally substituted by one, two or three substituents independently selected from halo, cyano, oxo, hydroxy, carboxy, R2, —OR2, —C(O)R2 or —C(O)OR2, and
• when R4 is optionally substituted C1-C6 alkyl and R5 is optionally substituted C1-C6 alkyl, then R4 and R5 together with the nitrogen atom to which they are attached in —C(O)NR4R5, —NR4R5, —SO2NR4R5, —NR3SO2NR4R5, —R3C(O)NR4R5 or —OC(O)NR4R5 may form a 3- to 6-membered heterocycloalkyl;
• R6, R7 and R8 are at each occurrence independently selected from hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, where
• any alkyl or cycloalkyl in R6, R7 and R8 may be optionally substituted by one, two or three substituents independently selected from halo, cyano, oxo, hydroxy, carboxy, R2a, —OR2a, —C(O)R2a, —C(O)OR2a, —C(O)NR2aR2b, —NR2aC(O)R2b, —NR2aR2b, —SO2NR2aR2b, —NR2aSO2R2b, —SR2a, —SO2R2a, —SO2OR2a, —OSO2R2a, —NR2SO2NR2aR2b, —NR2aC(O)NR2bR2c, —NR2aC(O)OR2b or —OC(O)NR2aR2b;
• R11 and R12 are independently selected from hydrogen and C1-C6 alkyl;
• and
• q is 0, 1 or 2;
• provided at least one of L2, Y, L3 and Z is not a bond;
• provided —SO2—(CH2)2—NH2 in Formula I is linked to the remainder of the compound of Formula I via a carbon atom;
• provided when X is a bond, then L1 is selected from a bond, —C(O)—, —OC(O)—, —NR3C(O)—, —NR3SO2—, —SO2— and —OSO2—;
• provided when Y is a bond, then L2 is selected from a bond, —C(O)—, —C(O)O—, —C(O)NR3—, —SO2NR3—, —SO2— and —SO2O;
• and
• provided the compound is not