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US 2022/0017513 A1Published application
Aromatic ring derivative as immunoregulation and preparation method and application of aromatic ring derivative
AssigneesShanghai Jemincare Pharmaceuticals Co., Ltd., Jiangxi Jemincare Group Co., Ltd
InventorsHongfu LU, Jianbiao PENG, Weiqiang XING, Haibing GUO
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Abstract
Relating to a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, and an application of the compound as an S1P1 agonist.
Claims21
A compound of formula (I) or a pharmaceutically acceptable salt thereof,
- wherein
- n is selected from 1, 2 and 3;
- R1 is independently selected from H, F, Cl, Br, OH, NH2, CN, CH3, CH2CH3 and CF3;
- R4 is independently selected from H, F, Cl, Br, OH, NH2, CN, CH3, CH2CH3 and CF3;
- or, R1 and R4 are connected together to form a C3-6 cycloalkyl;
- R2 is selected from H, halogen, OH, NH2, CN and C1-3 alkyl, the C1-3 alkyl is optionally substituted by one, two or three R;
- R3 is selected from C3-7 cycloalkyl, C3-7 cycloalkenyl, C2-6 alkenyl and 3-6 membered heterocycloalkyl, the C3-7 cycloalkyl, C3-7 cycloalkenyl, C2-6 alkenyl or 3-6 membered heterocycloalkyl is optionally substituted by one, two or three R;
- ring A is selected from phenyl and 6 membered heteroaryl, the phenyl and 6 membered heteroaryl are optionally substituted by one, two or three Ra;
- ring B is selected from 5 membered heteroaryl, the 5 membered heteroaryl is optionally substituted by Rb;
- Ra is independently selected from H, halogen, OH, NH2, CN and C1-3 alkyl, the C1-3 alkyl is optionally substituted by one, two or three R;
- Rb is selected from H, halogen, OH, NH2, CN and C1-3 alkyl, the C1-3 alkyl is optionally substituted by one, two or three R;
- R is independently selected from H, F, Cl, Br, OH, NH2, CN, C1-3 alkyl and CF3;
- T1 is selected from N and CH;
- T2 is selected from N and CH;
- L1 is selected from
- L2 is selected from single bond, O and S;
- the 5 membered heteroaryl, 6 membered heteroaryl and 3-6 membered heterocycloalkyl contain one, two or three heteroatoms or heteroatom groups independently selected from O, NH, S and N.
14 more elements
8-13. (canceled)
A compound of the following formula or a pharmaceutically acceptable salt thereof,
Dependencies are inferred from the claim text.