A method for continuous exchange of material by countercurrent contacting of a first fluid phase and a second fluid phase that are not fully miscible, wherein contacting is performed in a single apparatus, which is an apparatus of Centrifugal Partition Chromatography (CPC) apparatus type, into which only the first fluid phase and the second fluid phase are fed, excluding any other phase, said apparatus comprising a plurality of cells, with a stationary phase immobilised in each of the cells and a mobile phase passing through the stationary phase, and in that the following steps a), b), and c) are successively carried out:
- a) Step at which the mobile phase consists of the first fluid phase, and the stationary phase immobilised in the cells consists of the second fluid phase.
- b) Step at which the mobile phase consists of the second fluid phase, and the stationary phase immobilised in the cells consists of the first fluid phase.
- c) Repetition of the succession of steps a) and b);
- step b) being performed immediately after step a), and step c) being performed immediately after step b).