Systems and methods for controlling against aneurysm formation, growth and rupture, and improving post-rupture outcomes

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A method for improving a patient outcome for a subject having an intracranial hemorrhage, the method comprising;

• determining that the subject has the intracranial hemorrhage;
• positioning a vagus nerve stimulation system on the subject, the vagus nerve stimulation system being configured to provide an electrical stimulation to the vagus nerve of the subject;
• stimulating the vagus nerve of the subject with the vagus nerve stimulation system, based on the determination that the subject has the intracranial hemorrhage.

A method for decreasing a level of matrix metalloproteinase-9 (MMP-9) in subject, the method comprising:

• positioning a vagus nerve stimulation system on the subject, the vagus nerve stimulation system being configured to provide an electrical stimulation to the vagus nerve of the subject;
• and
• stimulating the vagus nerve of the subject with the vagus nerve stimulation system to decrease the level of MMP-9 in the brain of the subject.

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A method for decreasing a matrix degrading enzyme in a subject, the method comprising:

• positioning a vagus nerve stimulation system on the subject, the vagus nerve stimulation system being configured to provide an electrical stimulation to the vagus nerve of the subject;
• and
• stimulating the vagus nerve of the subject with the vagus nerve stimulation system to decrease the level of the matrix degrading enzyme in the brain of the subject.

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