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US 2022/0016225 A1Published application
Vaccine compositions and adjuvant
OwnerLowell A. Miller, Jack C. Rhyaninventors
Life of this patent
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Abstract
The immune response of an animal to a target immunogen may be enhanced by use of an adjuvant which includes low concentrations of killed cells of Mycobacterium avium subspecies avium in combination with mineral oil. The adjuvant may be used in vaccine compositions for the immunization of an animal against any target immunogen and is particularly preferred for use with immunocontraceptive vaccines such as GnRH immunocontraceptive vaccines conjugated with a Blue carrier protein.
Claims18
A method for immunocontraception of an animal which comprises administering an immunocontraceptive vaccine composition to said animal which comprises:
- a. an immunogen comprising GnRH or a GnRH immunogenic analog conjugated to a carrier protein, and
- b. an adjuvant comprising mineral oil and killed cells of Mycobacterium avium subspecies avium or Mycobacterium avium complex, the concentration of said killed cells of Mycobacterium avium being in an amount effective for inducing immunocontraception of said animal in a single dose.
Dependencies are inferred from the claim text.