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US 2022/0016172 A1Published application
Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions
AssigneeThe Johns Hopkins University
InventorsIvan M. Borrello, Kimberly A. Noonan
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Abstract
In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for treating cancer in a subject, comprising administering to the subject a composition comprising activated MILs.
Claims15
-21. (canceled)
A method for preparing a population of marrow infiltrating lymphocytes (MILs), comprising:
- a) growing MILs in vitro under a hypoxic condition for a first period of time;
- and
- b) growing the MILs under a normoxic condition for a second period of time following said growing in step a).
35-38. (canceled)
Dependencies are inferred from the claim text.