Method of administration and treatment

A formulation suitable for transdermal delivery of a buffering agent, the formulation comprising:

• the buffering agent comprising sodium bicarbonate or sodium carbonate, menthol, a penetrant or penetration enhancer, a source of fatty acids, and a polar solvent, and one or more of a humectant, an emulsifier, a surfactant, and an emollient;
• wherein the formulation is formulated as a cream, lotion, or ointment.

The formulation of claim 20, wherein the formulation comprises about 33% sodium bicarbonate or sodium carbonate and about 0.5% menthol.

A formulation suitable for transdermal delivery of a buffering agent comprising sodium bicarbonate or sodium carbonate, the formulation comprising about 33% w/w sodium bicarbonate and about 0.5% w/w menthol;

• wherein the formulation further comprises one or more of ethanol, benzyl alcohol, cetyl alcohol, almond oil, lecithin, isopropyl palmitate (IPP), propylene glycol, a poloxamer, water, and Durosoft®;
• and
• wherein the formulation is formulated as a cream, lotion, or ointment.