Methods and materials for identifying and treating bet inhibitor-resistant cancers
AssigneeMayo Foundation for Medical Education and Research
InventorHaojie Huang
Life of this patent
Estimating the term…
Abstract
This document provides methods and materials involved in identifying and treating mammals having a cancer resistant to BET inhibitors. For example, methods and materials for administering (a) one or more AKT inhibitors and/or one or more CDK inhibitors and/or one or more CBP/p300 inhibitors in combination with (b) one or more BET inhibitors to mammals identified as having a cancer resistant to treatment with one or more BET inhibitors in the absence of AKT, CDK, and CBP/p300 inhibitors are provided.
Claims13
1-8. (canceled)
A method for treating cancer, wherein said method comprises:
- (a) identifying a mammal as having a cancer at least partially resistant to BET inhibitor treatment,
- (b) administering a CDK inhibitor or a CBP/p300 inhibitor to said mammal to increase the susceptibility of said cancer to a BET inhibitor, and
- (c) administering a BET inhibitor to said mammal.
A method for treating cancer, wherein said method comprises:
- (a) administering a CDK inhibitor or a CBP/p300 inhibitor to a mammal identified as having a cancer at least partially resistant to BET inhibitor treatment to increase the susceptibility of said cancer to a BET inhibitor, and
- (b) administering a BET inhibitor to said mammal to reduce the number of cancer cells within said mammal.
A method for treating cancer, wherein said method comprises administering (a) a CDK inhibitor or a CBP/p300 inhibitor and (b) a BET inhibitor to a mammal identified as having a cancer at least partially resistant to BET inhibitor treatment.
Dependencies are inferred from the claim text.