Determining drug combinations, synergistic drug combination and use thereof in pancreatic cancer treatment

A method, comprising:

• retrieving, by one or more processors, pancreatic cancer datasets from a plurality of data sources based on selected types of expression profiling;
• determining, by the one or more processors, a set of feature genes based on differential gene expression analysis of disease samples and control samples in normalized Pancreatic cancer datasets;
• selecting, by the one or more processors, pancreatic cancer targets for combination analysis based on druggability and the determined set of feature genes;
• determining, by the one or more processors, a plurality of synergistic target pairs based on node embedded clustering of the selected pancreatic cancer targets,
• wherein one of each pair of target pair is an epidermal growth factor receptor inhibitor;
• selecting, by the one or more processors, candidate pairs of drug combinations from a plurality of pairs of drug combinations based on a cumulative ranking score of each pair of drug combination and the plurality of synergistic target pairs;
• and
• determining, by the one or more processors, one or more sets of drug combinations based on prioritization of the candidate pairs of drug combinations, filtration of drug combinations of the epidermal growth factor receptor inhibitor, and external validation.