Benzimidazole or benzoxazole derivatives for preventing and treating central nervous system disease, diabetes, and complications thereof

A pharmaceutical composition for preventing or treating a central nervous system (CNS) disease, diabetes and complications thereof, the pharmaceutical composition comprising, as an active ingredient, a benzimidazole or benzoxazole derivative having the structure of Formula 1, or a pharmaceutically acceptable salt thereof:

• in the formula,
• R1 is hydrogen, a halogen atom, a hydroxyl group, or substituted or unsubstituted C1-C6 alkyl,
• R2 and R3 are each independently hydrogen, a halogen atom, hydroxyl, a C1-C6 alkyl group, substituted or unsubstituted C1-C6 alkoxy, sulfonyl, sulfonic acid, or nitro, or R2 and R3 combine together to form an aryl ring,
• A is C1-C6 alkylene, NH, or (C1-C6 alkyl)-N,
• X is O, N, or NH, and
• Y is O, S, —SO—(CH2)n—R4, —S—(CH2)n—R4, —SO2—(CH2)n—R4, or —S—R5, wherein n is an integer of 1 to 3;
• R4 is pyridine unsubstituted or substituted with at least one selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, halo-C1-C6 alkoxy, and C1-C6 alkoxy-C1-C6 alkoxy;
• and
• R5 is hydrogen or C1-C6 alkyl.