Orally administered pharmaceutical composition comprising fab i inhibitors and method for preparing same
AssigneeCrystalGenomics, Inc.
InventorsJae Pyoung CHO, Joong Myung CHO
Life of this patent
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Abstract
The present invention relates to an orally administered pharmaceutical composition comprising Fab I inhibitors, and to a method for preparing same. The present invention may be applied effectively to bacterial infections resistant to antibiotics and the like. More specifically, the present invention can more rapidly initiate therapeutic effects by improving dissolution and elution rates. Furthermore, the present invention can improve the mixing and content uniformity in preparations by regulating the particle size.
Claims9
A pharmaceutical composition for oral administration comprising 1-(3-amino-2-methylbenzyl)-4-(2-thiophen-2-yl-ethoxy)-1H-pyridin-2-one or a salt thereof.
A method for preparing a pharmaceutical composition for oral administration, comprising:
- adding 4-benzyloxy-1H-pyridone, 2-methyl-3-nitro-benzylchloride and potassium tert-butoxide to dimethylformamide, and mixing them to react with heating;
- adding purified water and drying with heating to obtain a dried product;
- dissolving the dried product in an organic solvent and adding purified water for layer separation;
- recovering the organic layer to filter and concentrate it to obtain concentrates;
- re-concentrating the concentrates and adding hexane to obtain precipitates;
- dissolving the resulting precipitates, and cooling, filtering and drying them to obtain a dried product;
- and
- dissolving the resulting dried product in an organic solvent, adding iron chloride hexahydrate, activated carbon and hydrazine monohydrate thereto, cooling and filtrating them to obtain resulting precipitates and then drying and pulverizing it.
Dependencies are inferred from the claim text.