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US 2022/0016096 A1Published application
Gel containing pirfenidone
AssigneeExcalibur Pharmaceuticals, Inc.
InventorsJosé Agustín Rogelio Magaña Castro, Laura Vázquez Cervantes, Juan Socorro Armendáriz Borunda
Life of this patent
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Abstract
The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in treatment for the restoration of tissues with fibrotic lesions and for the prevention of fibrotic lesions.
Claims21
1-6. (canceled)
A composition of pirfenidone gel comprising:
- (a) 2-12% pirfenidone;
- (b) 0.4-1.2% of a viscous agent selected from the group consisting of Carbomer 940, Ultrex 10, cellulose derivatives, gums, and poloxamers;
- (c) 10-30% of a solubilizer selected from the group consisting of N-methylpyrrolidone, ethyl alcohol, and propylene glycol;
- (d) 5-15% of a non-ionic solubilizer;
- (e) 0.2-1% of a conserving agent selected from the group consisting of diazolidinyl urea, iodopropynyl butylcarbamate, methylparaben, propylparaben, and combinations of these conserving agents;
- (f) 0.4-1.2% of a neutralizer agent selected from the group consisting of primary, secondary and tertiary mono-, bi-, and triethanolamine aliphatic amines, and hydroxide alkaline metals;
- and
- (g) water.
5 more elements
Dependencies are inferred from the claim text.