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US 2022/0016070 A1Published application
Premixed, ready to use pharmaceutical compositions of amiodarone
AssigneeGood Health, LLC
InventorBasavaraj Siddalingappa
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Abstract
Liquid amiodarone compositions having improved stability during storage are disclosed. The compositions include amiodarone, preferably as the HCl salt, a cyclodextrin such as hydroxy propyl β cyclodextrin and a surfactant, and have a pH of 3-5.
Claims19
A liquid amiodarone composition suitable for parenteral administration, comprising:
- a) amiodarone or a pharmaceutically acceptable salt thereof;
- b) cyclodextrin;
- and
- c) and a surfactant,
- said liquid amiodarone composition having a pH of 3-5.0,
- wherein when said liquid amiodarone composition is stored in a pharmaceutically-acceptable container with an amount of an inert gas, at temperature of from about 5-25° C. for a period of at least about 6 months, the amiodarone retains at least about 90% of its starting concentration.
3 more elements
Dependencies are inferred from the claim text.