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US 2022/0016045 A1Published application
Methods for treating alzheimer's disease with donepezil transdermal system
AssigneeCorium, Inc.
InventorsEun Soo LEE, Amit K. JAIN, Parminder SINGH
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Abstract
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.
Claims10
A method for treating Alzheimer's disease, comprising:
- providing a transdermal delivery system comprising a drug reservoir comprising donepezil HCl and an alkaline salt, and
- applying the transdermal delivery system to the skin of a subject, thereby administering to the subject donepezil base generated in the drug reservoir by reaction of donepezil HCl and the alkaline salt.
Dependencies are inferred from the claim text.