Ballistic delivery and related particles, compositions, methods and systems
AssigneeCalifornia Institute of Technology
InventorsBenjamin J. LACCETTI, Julia A. KORNFIELD
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Abstract
Methods and systems and related particles and compositions that can be used to deliver a biologically active cargo such as a drug to a cornea of an individual, the delivery performed in a rapid, nonsurgical, and/or controllable fashion are described. Particularly, a method is described for controlled ballistic delivery of a cargo in a microparticle to the cornea of an individual, including a biologically active cargo.
Claims22
A method for controlled ballistic delivery of a biologically active cargo to the cornea of an individual comprising an epithelium layer and a stroma layer and an interface between the epithelium layer and the stroma layer, the method comprising
- ballistically delivering to the cornea a convex microparticle comprising the biologically active cargo optionally in combination with a carrier material, the convex microparticle having a diameter from 5 to 30 um and a density from 1 g/cc up to less than 20 g/cc,
- the ballistically delivering performed at a velocity equal to or higher than 100 m/s to set target regions of the cornea from the epithelium layer to the stroma layer of the cornea of the individual.
Dependencies are inferred from the claim text.