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US 2022/0011388 A1Published application
Methods to predict liver disease mortality using lipoprotein lp-z
AssigneesLipoScience, Inc., Beth Israel Deaconess Medical Center, Inc.
InventorsZhenghui Gordon Jiang, James D. Otvos, Irina Shalaurova, Elias J. Jeyarajah, Margery A. Connelly, Michael Curry, Nezam Afdhal, Yury Popov, Maria Perez-Matos
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Abstract
Described herein are methods for the determination of patient mortality from alcoholic hepatitis in biosamples by NMR spectroscopy and more specifically for the determination of a Z index score based on lipoprotein constituent LP-Z in blood plasma and serum.
Claims21
A method to predict patient mortality to alcoholic hepatitis comprising:
- acquiring an NMR spectrum of a biosample obtained from the subject;
- programmatically determining the concentration of LP-Z and total apoB-containing lipoproteins in the sample based on the NMR spectrum of the sample, wherein the NMR spectrum of the sample includes LP-X and LP-Z;
- and
- calculating a Z index score.
1 more element
A NMR analyzer comprising:
- a NMR spectrometer;
- a probe in communication with the spectrometer;
- and
- a controller in communication with the spectrometer configured to obtain NMR signal of a defined single peak region of NMR spectra associated with LP-Z of a fluid specimen in the probe and generate a patient report providing a LP-Z level.
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Dependencies are inferred from the claim text.