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US 2022/0011323 A1Published application
Method for diagnosis and treating peripheral neuropathies
AssigneesAssistance Publique-Hopitaux de Paris, Sorbonne Universite
InventorsOlivier BOURRON, Joe-Elie SALEM, Agnès HARTEMANN
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Abstract
The present invention relates to MGP as a new serum marker useful by itself or in combination with other markers for diagnosis of peripheral neuropathies, in particular in diabetic patients. The invention is also drawn to diagnosis kits for the implementation of this method.
Claims24
A method for determining the presence of peripheral neuropathy in a patient comprising:
- a) determining the level of dephosphorylated uncarboxylated Matrix gla protein (MGP) in a sample from said patient and optionally of other clinical markers;
- b) when other markers are used, combining the values obtained in a) through a function in order to obtain an end result;
- c) comparing the level of dephosphorylated uncarboxylated MGP measured in step a) or of the end value obtained in step b) to a predetermined threshold;
- wherein the patient has peripheral neuropathy if the level of dephosphorylated uncarboxylated MGP measured in step a) or of the end value obtained in step b) is higher than the threshold.
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A method for treating a patient in need thereof, comprising:
- a) determining the level of dephosphorylated uncarboxylated Matrix gla protein (MGP) in a sample from said patient and optionally of other clinical markers;
- b) when other markers are used, combining the values obtained in a) through a function in order to obtain an end result;
- and
- c) comparing the level of dephosphorylated uncarboxylated MGP measured in step a) or of the end value obtained in step b) to a predetermined threshold;
- wherein the patient has peripheral neuropathy if the level of dephosphorylated uncarboxylated MGP measured in step a) or of the end value obtained in step b) is higher than the threshold, and
- d) treating the patient when the patient is detected as having peripheral neuropathy.
3 more elements
Dependencies are inferred from the claim text.