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US 2022/0010023 A1Published application
Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof
AssigneesCity of Hope, Board of Regents, The University of Texas System
InventorsHong QIN, Larry W. KWAK
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Abstract
Provided herein are T cells expressing a chimeric antigen receptor (CAR) targeted to B cell activating factor receptor (BAFF-R). The CAR targeted to BAFF-R (BAFF-R CAR) described herein includes a domain that binds BAFF-R. Methods of making and using the BAFF-R CAR are also provided.
Claims1
A nucleic acid molecule encoding a chimeric antigen receptor, wherein the chimeric antigen receptor comprises an scFv targeted to BAFF-R;
- a transmembrane domain selected from:
- a CD4 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD8 transmembrane domain or variant thereof having 1-5 amino acid modifications, a CD28 transmembrane domain or a variant thereof having 1-5 amino acid modifications, and a CD3ξ transmembrane domain or a variant thereof having 1-5 amino acid modifications;
- a costimulatory domain;
- and CD3ξ signaling domain of a variant thereof having 1-5 amino acid modifications.
1 more element
Dependencies are inferred from the claim text.