Polynucleotide for safer and more effective immunotherapies
OwnerFrancisco MARTIN MOLINA, María TRISTÁN MANZANO +3inventors
InventorsFrancisco MARTIN MOLINA, María TRISTÁN MANZANO, Noella MALDONADO PÉREZ, Karim BENABDELLAH EL KHLANJI, Pilar MUNOZ FERNÁNDEZ
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Abstract
The present invention provides polynucleotides and viral vectors for transfection of a mammalian host cell, preferably lentiviral vectors, encoding at least one CAR (chimeric antigen receptors)and a promoter from the Wiskott-Aldrich syndrome locus, in particular the promoter of SEQ. ID NO 1, operably linked to the CAR in order to drive its expression.
Claims13
A polynucleotide comprising i) a nucleotide sequence encoding a specific chimeric antigen receptor (CAR) and ii) a promoter from the Wiskott-Aldrich syndrome locus or a fragment of said promoter comprising SEQ ID NO 2 or a nucleotide sequence having at least 70% identity with SEQ ID NO 2, wherein said promoter is operably linked to the nucleotide sequence encoding the CAR in order to drive the expression of the chimeric antigen receptor, and wherein the CAR comprises at least one extracellular ligand binding domain, a transmembrane domain and at least one intracellular signalling domain.
Dependencies are inferred from the claim text.