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US 2022/0009928 A1Published application
Solid forms of a toll-like receptor modulator
AssigneeGilead Sciences, Inc.
InventorsKrista Marie Diaz, Patricia Andres, Valeriya N. Smolenskaya
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Abstract
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
Claims21
-56. (canceled)
A crystalline form of Compound I having the structure:
- characterized by an X-ray powder diffraction (XRPD) pattern comprising three or more peaks at 5.5, 9.4, 10.8, 11.9, 12.9, 14.4, 16.0, 19.0, 21.9, or 23.9 degrees 2θ (±0.2 degrees 2θ), wherein the XRPD is made using CuKα1 radiation.
A pharmaceutical composition comprising a crystalline form of Compound I having the structure:
- characterized by an X-ray powder diffraction (XRPD) pattern comprising three or more peaks at 5.5, 9.4, 10.8, 11.9, 12.9, 14.4, 16.0, 19.0, 21.9, or 23.9 degrees 2θ (±0.2 degrees 2θ), wherein the XRPD is made using CuKα1 radiation, and a pharmaceutically acceptable carrier or excipient.
A method of preparing a crystalline form of Compound I having the structure:
- characterized by an X-ray powder diffraction (XRPD) pattern comprising three or more peaks at 5.5, 9.4, 10.8, 11.9, 12.9, 14.4, 16.0, 19.0, 21.9, or 23.9 degrees 2θ (±0.2 degrees 2θ), wherein the XRPD is made using CuKα1 radiation,
- the method comprising forming a mixture comprising crystalline Form I of Compound I and chloroform under conditions suitable to prepare the crystalline form of Compound I.
Dependencies are inferred from the claim text.