Adamts inhibitors, preparation methods and medicinal uses thereof

A compound of formula (I), or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof:

• wherein:
• G1, G2, G3 and G4 are each independently N or CR6, provided that no more than two of them are N;
• R1 is selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, heterocyclyl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, alkyl, alkoxy, hydroxyalkyl, SO2R11a, NR11aR11b, C(═O)OR11a, C(═O)NR11aR11b, NHC(═O)R11a, NHC(═O)OR11a, cycloalkyl, heterocyclyl, and heteroaryl;
• R2a and R2b are each identical or different, and each is independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, hydroxy, haloalkyl, haloalkoxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, NR12aR12b, C(═O)OR12a, C(═O)NR12aR12b, NHC(═O)R12a, NHC(═O)OR12a, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R3b is selected from the group consisting of hydrogen, alkyl, hydroxy, haloalkyl, hydroxyalkyl, amino, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, NR12aR12b, C(═O)OR12a, C(═O)NR12aR12b, NHC(═O)R12a, NHC(═O)OR12a, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• or alternatively two of R2a, R2b and R3b together form cycloalkyl or heterocyclyl;
• R4a, R4b, R5a and R5b are each identical or different, and each is independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, alkoxy, hydroxy, haloalkyl, haloalkoxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, and heteroaryl;
• or alternatively two of R4a, R4b, R5a and R5b together form cycloalkyl or heterocyclyl;
• each R6 is identical or different and at each occurrence is independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, SO2R13a, SO2NR13aR13b, NR13aR13b, C(═O)OR13a, C(═O)NR13aR13b, NHC(═O)R13a, NHC(═O)OR13a, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, alkyl, alkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, SO2R14a, SO2NR14aR14b, NR14aR14b, C(═O)OR14a, C(═O)NR14aR14b, NHC(═O)R14a, NHC(═O)OR14a, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• each of R11a, R12a, R13a, and R14a is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, alkoxy, alkyl, and cycloalkyl;
• each of R11b, R12b, R13b, and R14b is independently selected from the group consisting of hydrogen and alkyl, wherein alkyl is optionally substituted with one or more groups independently selected from the group consisting of halogen, hydroxyl and alkoxy;
• n is 1 or 2;
• and
• m is 1 or 2.