(r) enanatiomer of aplexone
AssigneeThe Regents of the University of California
InventorsOyhun KWON, Qihai XU, Nathan J. DUPPER, Jau-Nian CHEN, Adam D. LANGENBACHER
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Abstract
R-aplexone, methods of preparing R-aplexone, or aplexone substantially free of its S-stereoisomer are disclosed. Methods of using R-aplexone or a pharmaceutically acceptable salt or solvate thereof to treat and/or prevent disease are disclosed. Methods of preparing 6-substituted tetrahydropyridine motifs with high enantiomeric excess are also disclosed.
Claims23
A composition comprising aplexone, aplexone having a structure of Formula I or a pharmaceutically acceptable salt or solvate thereof, the composition being substantially free of S-stereoisomer of aplexone (S-aplexone)
-5. (canceled)
-13. (canceled)
A method of preparing a compound having a general formula of Formula III
- wherein Ar1 and Ar2 are independently an aryl,
- the compound having an enantiomeric excess greater than about 80%,
- wherein the method comprises the reaction according to the Scheme I
-27. (canceled)
Dependencies are inferred from the claim text.