Polymorphic form of meisoindigo and modified formulation of meisoindigo
AssigneeNatrogen Therapeutics International, Inc.
InventorLonggui Wang
Life of this patent
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Abstract
The present invention relates to a novel crystal form, manufacturing procedures, pharmaceutical compositions, formulations and medicaments comprising a N-methylisoindigo crystalline, methods of preparation, and the use of the N-methylisoindigo crystalline to prepare a medicament to prevent cancer, or treat cancer or an inflammatory-related disease associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines.
Claims20
A solid form of N-methylisoindigo or a solid crystal form of N-methylisoindigo (Crystal Form I) having an X-ray powder diffraction pattern comprising a peak, in terms of 2-theta, at about 7.71°.
A pharmaceutical composition comprising a solid form of N-methylisoindigo or a solid crystal form of N-methylisoindigo (Crystal Form I) having an X-ray powder diffraction pattern comprising a peak, in terms of 2-theta, at about 7.71° and a pharmaceutically acceptable carrier.
A process for preparing a solid form of N-methylisoindigo or a solid crystal form of N-methylisoindigo (Crystal Form I) having an X-ray powder diffraction pattern comprising a peak, in terms of 2-theta, at about 7.71°, the process comprising precipitating a crystalline form from a solution comprising an organic solvent.
Dependencies are inferred from the claim text.