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US 2022/0008545 A1Published application
BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR FAPa
AssigneeBicycleRD Limited
InventorsLiuhong CHEN, Catherine STACE, Edward WALKER
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AssigneeBicycleRD Limited
InventorsLiuhong CHEN, Catherine STACE, Edward WALKER
Estimating the term…
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of fibroblast activation protein a (FAPα). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by FAPα.
A peptide ligand specific for FAPα comprising a polypeptide comprising at least three cysteine residues, separated by at least two loop sequences, and a molecular scaffold which forms covalent bonds with the cysteine residues of the polypeptide such that at least two polypeptide loops are formed on the molecular scaffold.
Dependencies are inferred from the claim text.