MULTI-FUNCTIONALIZED noMV CONJUGATES
AssigneeGlaxosmithkline Biologicals SA
InventorsRenzo ALFINI, Roberta DI BENEDETTO, Francesca MICOLI, Allan James SAUL
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Abstract
The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.
Claims19
An immunogenic conjugate comprising a native outer membrane vesicle (nOMV), having at least a surface saccharide moiety connected to an antigen, and at least a surface protein residue connected to a different antigen through a bivalent linker.
Dependencies are inferred from the claim text.