Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
AssigneeNovartis AG
InventorsEric Legangneux, Alexandros Sagkriotis, Pierre Jordaan, Florine Polus, Alan John Camm, Shibadas Biswal, Parasar Pal, Uday Kiran Veldandi, Atul Keshav Pawar, Vassilios Aslanis, Kasra Shakeri-Nejad
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Abstract
The present invention relates to methods of treating autoimmune diseases with siponimod in patients receiving additionally a beta-blocker.
Claims43
A method of treating an autoimmune disease in a patient comprising
- a) administering to said patient an initial titration regimen of siponimod;
- b) administering to said patient 1-15 mg siponimod daily as a maintenance regimen;
- and
- c) introducing in said patient a beta-blocker treatment the earliest at the first day when said patient is receiving the dosage of the maintenance regimen;
- wherein said initial titration regimen comprises administering siponimod at a dosage lower than the dosage of the maintenance regimen and then increasing the dosage stepwise up to the dosage of the maintenance regimen.
A method of treating an autoimmune disease in a patient receiving a chronic beta-blocker treatment and having a resting heart rate of >50 bpm under said chronic beta-blocker treatment comprising introducing in said patient a siponimod treatment by
- a) administering to said patient an initial titration regimen of siponimod;
- and
- b) administering to said patient 1-15 mg siponimod daily as a maintenance regimen;
- wherein said initial titration regimen comprises administering siponimod at a dosage lower than the dosage of the maintenance regimen and then increasing the dosage stepwise up to the dosage of the maintenance regimen.
A method of treating an autoimmune disease in a patient receiving a chronic beta-blocker treatment and having a resting heart rate of ≤50 bpm under said chronic beta-blocker treatment comprising
- a) interrupting said chronic beta-blocker treatment in said patient until the baseline heart-rate is >50 bpm;
- b) initiating in said patient a siponimod treatment by
- b1) administering to said patient an initial titration regimen of siponimod;
- and
- b2) administering to said patient 1-15 mg siponimod daily as a maintenance regimen;
- and
- c) re-initiating in said patient a beta-blocker treatment the earliest at the first day when said patient is receiving the dosage of the maintenance regimen;
- wherein said initial titration regimen comprises administering siponimod at a dosage lower than the dosage of the maintenance regimen and then increasing the dosage stepwise up to the dosage of the maintenance regimen.
Dependencies are inferred from the claim text.