Macrocyclic compounds and uses thereof
AssigneeAalto University Foundation sr
InventorsChristopher JONKERGOUW, Kodiah BEYEH, Ekaterina OSMEKHINA, Robin RAS, Markus LINDER
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Abstract
This invention relates to macrocyclic cavity containing compounds and uses thereof in inhibiting a microbial signalling molecule or in reducing the amount of a microbial signalling molecule in a subject. The invention also relates to methods for inhibiting a microbial signalling molecule or for reducing the amount of a microbial signalling molecule in a subject by contacting a macrocyclic cavity-containing compound with said subject.
Claims33
1-24. (canceled)
A method to inhibit a microbial quorum signalling molecule or to reduce the amount of a microbial quorum signalling molecule produced by a Gram-negative bacteria in a subject, by binding the microbial quorum signaling molecule by non-covalent host-guest bonding by a macrocyclic cavity-containing compound, wherein the method comprises contacting the macrocyclic, cavity-containing compound selected from pillar arenes, cucurbiturils crown ethers and/or salts thereof with said subject.
(canceled)
(canceled)
A method to prevent or treat a microbial quorum signalling molecule dependent and/or mediated infection in a subject or a medium, which infection is caused by a Gram-negative bacteria by binding the microbial quorum signaling molecule by non-covalent host-guest bonding by a macrocyclic cavity-containing compound, wherein the method comprises contacting the macrocyclic cavity-containing compound selected from pillar arenes, cucurbiturils, crown ethers and/or salts thereof with said subject or medium.
A method to reduce or abolish virulence in a Gram-negative bacteria by non-covalent host-guest bonding between a macrocyclic cavity-containing compound and a microbial quorum signaling molecule produced by a Gram-negative bacteria, wherein the macrocyclic cavity-containing compound is selected from pillar arenes, cucurbiturils, crown ethers and/or salts thereof.
Dependencies are inferred from the claim text.