Self-Assembled Microcapsules With Stimuli-Responsive Organic Ligands
AssigneeThe Regents of the University of California
InventorsRyan Baxter, Sayantani Ghosh
Life of this patent
Estimating the term…
Abstract
Self-assembled organic ligand functionalized microcapsules encapsulating one or more substrates, which release the substrates upon activation with a power source, are provided. Compositions that include these microcapsules, as well as methods of making the microcapsules and releasing the encapsulated substrates are also provided. The structures, compositions and methods find use in a variety of applications, such as drug and cell encapsulation technologies, for direct delivery, control, and activation of medicines and therapies to specific tissues in a living host.
Claims64
A self-assembled microcapsule comprising:
- nanoparticles;
- and
- stimuli-responsive organic ligands attached to said nanoparticles;
- wherein the organic ligands undergo electron transfer upon activation with one or more external stimulus to produce a nanomaterial with openings.
A method of delivering one or more substrates to an individual, the method comprising:
- administering an effective amount of a self-assembled microcapsule comprising:
- nanoparticles;
- stimuli-responsive organic ligands attached to said nanoparticles;
- and one or more substrates encapsulated inside the microcapsule, to an individual;
- and
- applying one or more external stimulus, wherein the organic ligands undergo electron transfer upon activation with the external stimulus to rupture the microcapsule and release the one or more substrates.
Dependencies are inferred from the claim text.