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US 2022/0003768 A1Published application
Serological biomarkers for early diagnosis of lung cancer
AssigneesCdi Laboratories, Inc., The Johns Hopkins University
InventorsIgnacio PINO, Heng ZHU, Jiang QIAN, Yi HUANG
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Abstract
Biomarkers to screen for, identify, and/or characterize lung cancer in a subject with high selectivity and high specificity are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.
Claims71
A method comprising:
- a. contacting a sample from a subject suspected of having a cancer with one or more isolated and purified tumor-associated proteins, wherein the one or more isolated and purified tumor-associated proteins comprise at least one selected from the group consisting of:
- tripartate motif containing 33 (TRIMM33), BCL tumor suppressor 7A (BCL7A), Prostatic acid phosphatase (ACPP), mitochondrial transcription termination factor 4 (MTERF4), Sulfotransferase family cytosolic 2B member 1 (SULT2B1), Tetratricopeptide repeat protein 1 (TTC1), a polypeptide having at least 80 percent sequence identity with a sequence as shown in one of SEQ ID NO:
- 121, SEQ ID NO:
- 124, SEQ ID NO:
- 126, SEQ ID NO:
- 141, SEQ ID NO:
- 142, SEQ ID NO:
- 149, and any combination thereof.
5 more elements
An in vitro composition that comprises:
- a. at least two tumor-associated proteins, wherein the at least two isolated and purified tumor-associated proteins comprise at least one selected from the group consisting of:
- tripartate motif containing 33 (TRIMM33), BCL tumor suppressor 7A (BCL7A), Prostatic acid phosphatase (ACPP), mitochondrial transcription termination factor 4 (MTERF4), Sulfotransferase family cytosolic 2B member 1 (SULT2B1), Tetratricopeptide repeat protein 1 (TTC1), a polypeptide having at least 80 percent sequence identity with a sequence as shown in one of SEQ ID NO:
- 121, SEQ ID NO:
- 124, SEQ ID NO:
- 126, SEQ ID NO:
- 141, SEQ ID NO:
- 142, SEQ ID NO:
- 149, and any combination thereof, and
- b. a moiety bound to at least one of the at least two tumor-associated proteins, wherein the moiety is present in a sample obtained from a subject suspected of having a cancer.
6 more elements
A solid support that comprises:
- two or more isolated and purified tumor-associated proteins attached thereto, wherein at least two of the two or more isolated and purified tumor-associated proteins are selected from the group consisting of:
- tripartate motif containing 33 (TRIMM33), BCL tumor suppressor 7A (BCL7A), Prostatic acid phosphatase (ACPP), mitochondrial transcription termination factor 4 (MTERF4), Sulfotransferase family cytosolic 2B member 1 (SULT2B1), Tetratricopeptide repeat protein 1 (TTC1), a polypeptide having at least 80 percent sequence identity with a sequence as shown in one of SEQ ID NO:
- 121, SEQ ID NO:
- 124, SEQ ID NO:
- 126, SEQ ID NO:
- 141, SEQ ID NO:
- 142, SEQ ID NO:
- 149, and any combination thereof.
5 more elements
Dependencies are inferred from the claim text.