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US 2021/0363144 A1Published application
Pyrrolo(pyrazolo)pyrimidine derivative as lrrk2 inhibitor
AssigneeOscotec Inc.
InventorsJung-Ho KIM, Jang-Sik CHOI, Song-Eun PARK, Hwa Sil KIM, Dong-Sik JUNG, Jong-Sung KOH, Se-Won KIM, Jaekyoo LEE
Life of this patent
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Abstract
The present invention relates to a pyrrolo(pyrazolo)pyrimidine derivative having efficacy as an LRRK2 inhibitor, a preparation method therefor, and a pharmaceutical composition for preventing or treating degenerative brain diseases, containing the same.
Claims18
A compound selected from the group consisting of a compound represented by the following Formula 1, and a pharmaceutically acceptable salt, hydrate, solvate, prodrug, and isomer thereof:
- in the above formula,
- X is CH or N;
- R1 is hydrogen, halogen, or C1-4 alkyl or C1-4 alkoxy unsubstituted or substituted with one or more halogens;
- R2 is C1-6 alkyl, C1-3 alkoxy C1-6 alkyl, C3-6 cycloalkyl C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl, 4- to 7-membered heterocycloalkyl, or C6-10 aryl unsubstituted or substituted with one or more halogens;
- wherein the 4- to 7-membered heterocycloalkyl may be substituted with C1-4 alkyl, C1-4 alkylcarbonyl unsubstituted or substituted with one or more halogens, C3-6 cycloalkylcarbonyl, 4- to 7-membered heterocycloalkylcarbonyl unsubstituted or substituted with C1-4 alkyl, C1-4 alkylsulfonyl, C3-6 cycloalkylsulfonyl, or oxetanyl, and
- the heterocycloalkyl contains at least one atom selected from N, O, and S,
- R3 is hydrogen, halogen, or C1-4 alkyl;
- R4 is C1-6 alkyl or C3-6 cycloalkyl unsubstituted or substituted with one or more halogens;
- and
- R5 is halogen, or C1-4 alkyl unsubstituted or substituted with one or more halogens.
7 more elements
11-12. (canceled)
Dependencies are inferred from the claim text.