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US 2021/0352887 A1Published application
Oxygenation media for ex-vivo preservation of organs and tissues
AssigneeVirTech Bio, Inc.
InventorWilliam Richard Light
Life of this patent
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AssigneeVirTech Bio, Inc.
InventorWilliam Richard Light
Estimating the term…
Oxygenation constituents and finished oxygenation media, as well as methods of making oxygenation constituents and finished oxygenation media are provided. The oxygenation constituents comprise a hemoglobin preparation, and a red blood cell preparation. The oxygenation constituents comprise from about 10% to about 99% by weight hemoglobin of the hemoglobin preparation and the balance by weight hemoglobin of the oxygenation constituents comprise a red blood cell preparation. The finished oxygenation media comprise the oxygenation constituents and one or more other ingredients such as a diluent, or excipient. The finished oxygenation media can be used to ex-vivo preserve organs or tissue.
An oxygenation constituent for formulating a finished oxygenation medium, the oxygenation constituent comprising a mixture of a first and second preparation wherein:
A finished oxygenation medium comprising:
A method of preparing a finished oxygenation medium for ex-vivo use, the method comprising:
A use of an oxygenation constituent to formulate a finished oxygenation medium, the oxygenation constituent comprising:
A use of a finished oxygenation medium for the ex-vivo preservation of a tissue or an organ, the finished oxygenation medium comprising:
An organ preservation system comprising a circuitous perfusion fluid system operable to perfuse a perfusion fluid through an organ, the preservation system comprising a fluid reservoir to support an organ, the fluid reservoir in fluid connection with a continuous or semi-continuous supply assembly for supplying a perfusion fluid or an excipient to the fluid reservoir, the fluid reservoir further in fluid connection with a separation device permitting the filtration of the perfusion fluid upon removal of the perfusion fluid from the fluid reservoir to separate and remove spent constituents from the perfusion fluid, and a pump for circulating the perfusion fluid through the circuitous fluid system.
A composition, system and/or method comprising any combination of one or more of the features described above and/or claimed above.
Dependencies are inferred from the claim text.