Cross-variant polygenic predictive data analysis

An apparatus for cross-variant polygenic risk modeling for a target individual in relation to a target medical condition, the apparatus comprising at least one processor and at least one memory including program code, the at least one memory and the program code configured to, with the processor, cause the apparatus to at least:

• generate, for each genetic variant of a plurality of genetic variants that is associated with a chromosome of a plurality of chromosomes, a per-variant genetic risk score of a plurality of per-variant genetic risk scores based on:
• (i) a per-variant risk probability value for the genetic variant in relation to the target medical condition that is selected from a plurality of per-variant risk probability values for the plurality of genetic variants, and (ii) a per-variant allele count for the genetic variant in relation to the target individual that is selected from a plurality of per-variant allele counts for the plurality of genetic variants;
• generate a genetic risk profile for the plurality of genetic variants, wherein:
• (i) the genetic risk profile comprises one or more per-chromosome profile segments each associated with a chromosome of the plurality of chromosomes, and (ii) each per-chromosome profile segment of the one or more per-chromosome profile segments that is associated with a respective chromosome of the plurality of chromosomes comprises each per-variant genetic risk score for a genetic variant in a subset of the plurality of genetic variants that is associated with the respective chromosome;
• and
• performing one or more prediction-based actions based on the genetic risk profile.

A computer program product for cross-variant polygenic risk modeling for a target individual in relation to a target medical condition, the computer program product comprising at least one non-transitory computer-readable storage medium having computer-readable program code portions stored therein, the computer-readable program code portions configured to:

• generate, for each genetic variant of a plurality of genetic variants that is associated with a chromosome of a plurality of chromosomes, a per-variant genetic risk score of a plurality of per-variant genetic risk scores based on:
• (i) a per-variant risk probability value for the genetic variant in relation to the target medical condition that is selected from a plurality of per-variant risk probability values for the plurality of genetic variants, and (ii) a per-variant allele count for the genetic variant in relation to the target individual that is selected from a plurality of per-variant allele counts for the plurality of genetic variants;
• generate a genetic risk profile for the plurality of genetic variants, wherein:
• (i) the genetic risk profile comprises one or more per-chromosome profile segments each associated with a chromosome of the plurality of chromosomes, and (ii) each per-chromosome profile segment of the one or more per-chromosome profile segments that is associated with a respective chromosome of the plurality of chromosomes comprises each per-variant genetic risk score for a genetic variant in a subset of the plurality of genetic variants that is associated with the respective chromosome;
• and
• performing one or more prediction-based actions based on the genetic risk profile.