Method for predicting genotype by using snp data
AssigneeGenealogy Inc.
InventorsBuhm Han, Seung Ho Cook
Life of this patent
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Abstract
A method for predicting a genotype using SNP data is disclosed. An embodiment includes steps of receiving SNP data to be analyzed and reference data, of updating the reference data by inserting a marker corresponding to a genotype of the SNP data corresponding to each of a plurality of predetermined regions included in corresponding SNP data, for each SNP data included in the reference data, and of predicting a genotype of the SNP data to be analyzed based on the SNP data to be analyzed and the updated reference data.
Claims20
A method of predicting a genotype using single nucleotide polymorphism (SNP) data, the method comprising:
- acquiring SNP data to be analyzed;
- acquiring reference data comprising a plurality of pieces of SNP data with determined genotypes;
- updating the reference data by inserting a marker corresponding to a genotype of corresponding SNP data into each of a plurality of predetermined regions included in the corresponding SNP data, for each of the plurality of pieces of SNP data included in the reference data;
- and
- predicting a genotype of the SNP data to be analyzed, based on the SNP data to be analyzed and the updated reference data.
A method of predicting a genotype using single nucleotide polymorphism (SNP) data, the method comprising:
- acquiring SNP data to be analyzed;
- acquiring reference data comprising a plurality of pieces of SNP data with determined genotypes;
- sampling the SNP data to be analyzed and the plurality of pieces of SNP data;
- calculating a transition probability between states corresponding to the genotypes of the plurality of pieces of SNP data in a hidden Markov model (HMM), based on the sampled data;
- acquiring a genetic distance between the states by converting the transition probability between the states;
- and
- predicting a genotype of the SNP data to be analyzed, based on the genetic distance, the reference data, and the SNP data to be analyzed.
An apparatus for predicting a genotype using single nucleotide polymorphism (SNP) data, the apparatus comprising:
- a memory configured to store SNP data to be analyzed, and reference data comprising a plurality of pieces of SNP data with determined genotypes;
- and
- a processor configured to update the reference data by inserting a marker corresponding to a genotype of corresponding SNP data into each of a plurality of predetermined regions included in the corresponding SNP data, for each of the plurality of pieces of SNP data included in the reference data, and to predict a genotype of the SNP data to be analyzed, based on the SNP data to be analyzed and the updated reference data.
Dependencies are inferred from the claim text.