Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

A system for tracking efficacy of a medical treatment for a plaque-based disease based on non-invasive medical image analysis, the system comprising:

• one or more computer readable storage devices configured to store a plurality of computer executable instructions;
• and
• one or more hardware computer processors in communication with the one or more computer readable storage devices and configured to execute the plurality of computer executable instructions in order to cause the system to:
• access a first set of plaque parameters and a first set of vascular parameters associated with a subject, wherein the first set of plaque parameters and the first set of vascular parameters are derived from a first medical image of the subject comprising one or more regions of plaque, wherein the first medical image of the subject is obtained non-invasively at a first point in time, wherein the first set of plaque parameters comprises one or more of density, location, or volume of one or more regions of plaque derived from the first medical image of the subject obtained at the first point in time, and wherein the first set of vascular parameters comprises one or more of vascular parameters such as volume, diameter, area, length, location, or remodeling derived from the first medical image of the subject obtained at the first point in time;
• access a second medical image of the subject, wherein the second medical image of the subject is obtained non-invasively at a second point in time after the subject is treated with a medical treatment, the second point in time being later than the first point in time, wherein the second medical image of the subject comprises the one or more regions of plaque;
• identify the one or more regions of plaque from the second medical image;
• determine a second set of plaque parameters and a second of vascular parameters associated with the subject by analyzing the one or more regions of plaque identified from the second medical image, wherein the second set of plaque parameters comprises one or more of density, location, or volume of the one or more regions of plaque derived from the second medical image of the subject obtained at the second point in time, and wherein the second set of vascular parameters comprises one or more of vascular parameters such as volume, diameter, area, length, location, or remodeling derived from the second medical image of the subject obtained at the second point in time;
• analyze one or more changes between the first set of plaque parameters and the second set of plaque parameters;
• analyze one or more changes between the first set of vascular parameters and the second set of vascular parameters;
• track progression of the plaque-based disease based at least in part on one or more of the analyzed one or more changes between the first set of plaque parameters and the second set of plaque parameters or the analyzed one or more changes between the first set of vascular parameters and the second set of vascular parameters;
• and
• determine efficacy of the medical treatment based on the tracked progression of the plaque-based disease.