Predicting antibiotic resistance and complementary antibiotic combinations

A system, comprising:

• a memory that stores computer executable components;
• a processor that executes the computer executable components stored in the memory, wherein the computer executable components comprise:
• a protein identification component that identifies one or more proteins that have one or more functional domains associated with at least one code selected from a coding system for a set of phenotypes;
• and
• a vectorization component that models the one or more proteins as a functional capacity vector.

A method comprising:

• generating, by a system comprising a processor, a reference data structure that identifies different genomes, antimicrobial resistance statuses of the different genomes to different antibiotic compounds, and functional capacity vectors for the different genomes, wherein the functional capacity vectors represent sets of phenotypic features expressed by the different genomes in association with exposure to the different antibiotic compounds;
• generating, by the system, a target functional capacity vector for a target genome excluded from the reference data structure;
• and
• employing, by the system, the reference data structure and the target functional capacity vector to determine one or more of the antibiotic compounds to which the target genome is susceptible.

A system, comprising:

• a memory that stores computer executable components;
• a processor that executes the computer executable components stored in the memory, wherein the computer executable components comprise:
• a reference data generation component that generates a reference data structure identifying different genomes, antimicrobial resistance statuses of the different genomes to different antibiotic compounds, and functional capacity vectors for the different genomes, wherein the functional capacity vectors represent sets of phenotypic features expressed by the different genomes in association with exposure to the different antibiotic compounds;
• a vectorization component that generates a target functional capacity vector for a target genome excluded from the reference data structure;
• and
• a susceptibility forecasting component that employs the reference data structure and the target functional capacity vector to determine one or more of the antibiotic compounds to which the target genome is susceptible.