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AssigneeThe Regents of the University of California
InventorsJulie Beth Sneddon, Lauren E. Byrnes, Daniel M. Wong
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The disclosure provides methods for enriching for pancreatic endocrine progenitor cells, such as human pancreatic endocrine progenitor cells, including alpha cell progenitors, beta cell progenitors, delta cell progenitors, PP cell progenitors and epsilon cell progenitors. The disclosure provides mammalian, such as human, Fev+ pancreatic endocrine progenitor cells, including Fev+ alpha cell progenitors, Fev+ beta cell progenitors, Fev+ delta cell progenitors, Fev+ PP cell progenitors, and Fev+ epsilon cell progenitors. The disclosure further provides methods for producing or inducing such cells, including in vitro differentiation methods, and the cells so produced.
A method of enriching the pancreatic endocrine progenitor cell population in a cell sample comprising
A method of producing a pancreatic endocrine progenitor cell comprising culturing a stem cell under conditions that induce differentiation of the stem cell into a pancreatic endocrine progenitor cell comprising the E26 transformation-specific transcription factor Fev.
A method of inducing formation of a hormone-producing cell comprising contacting a progenitor of a hormone-producing cell with an effective amount of Fev to produce a hormone-producing cell.
A method of screening for a signaling compound that induces FEV+ progenitor cell replication comprising:
A method of screening for a signaling compound that enhances FEV+ progenitor cell differentiation into beta cells comprising:
Dependencies are inferred from the claim text.