System and method for production of on-demand proteins in a portable unit for point of care delivery
AssigneeUniversity of Maryland, Baltimore County
InventorsGovind RAO, Yordan KOSTOV, Leah TOLOSA, Xudong GE, Douglas Frey
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Abstract
A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
Claims20
A method of stimulating production of granulocytes in a patient undergoing cancer therapy, said method comprising administering a Granulocyte Colony Stimulating Factor (G-CSF) protein to the patient, wherein the G-CSF is synthesized on-demand in a bioprocessing system using cell-free protein expression, said bioprocessing system comprising:
- a production module for producing non-purified G-CSF protein, and
- a purification module for receiving the non-purified G-CSF protein from the production module and for purifying the G-CSF protein from reagents.
A method of treating anemia in a patient in need thereof, said method comprising administering Erythropoetin (EPO) to the patient, wherein the EPO is synthesized on-demand in a bioprocessing system using cell-free protein expression, said bioprocessing system comprising:
- a production module for producing non-purified EPO protein, and
- a purification module for receiving the non-purified EPO protein from the production module and for purifying the EPO protein from reagents.
A method of treating a clot or achieving thrombolysis in a patient in need thereof, said method comprising administering Streptokinase to the patient, wherein the Streptokinase is synthesized on-demand in a bioprocessing system using cell-free protein expression, said bioprocessing system comprising:
- a production module for producing non-purified Streptokinase protein, and
- a purification module for receiving the non-purified Streptokinase protein from the production module and for purifying the Streptokinase protein from reagents.
Dependencies are inferred from the claim text.