Alginate hollow microfiber

A method for manufacturing an alginate gel fiber formed by covering a core layer comprising antibody-producing cells and a base material with a shell layer comprising an alginate gel having greater mechanical strength than the core layer, wherein

• the method for manufacturing an alginate gel fiber uses a microfluidic device 10 comprising an introduction pipe 40, an inlet 1 of the introduction pipe 40, an inlet 2 of the introduction pipe 40 located downstream from the inlet 1, an inlet 3 of the introduction pipe 40 located downstream from the inlet 2, and an outlet 50 of the introduction pipe 40 located downstream from the inlet 2, and comprises
• (1) a step of forming a first laminar flow of the antibody-producing cells 6 and the base material in the introduction pipe 40 by introducing antibody-producing cells 6 and a base material from the inlet 1 and injecting the same,
• (2) a step of forming a second laminar flow of the sodium alginate solution covering the outer circumference of the first laminar flow by introducing a sodium alginate solution from the inlet 2 and injecting the same,
• (3) a step of forming a third laminar flow of the solution comprising the divalent metal ion covering the outer circumference of the second laminar flow by introducing a solution comprising a divalent metal ion from the inlet 3 and injecting the same, and
• (4) a step of obtaining an alginate gel fiber formed by covering a core layer comprising antibody-producing cells and a base material that are ejected from the outlet 50 with a shell layer comprising an alginate gel.

An alginate gel fiber comprising:

• a core layer;
• and
• a shell layer disposed on the core layer,
• wherein the core layer comprises antibody-producing cells and a base material, the shell layer comprises an alginate gel, and the shell layer has a greater mechanical strength than the core layer.