Systems and method of precision functional mapping-guided interventional planning
AssigneeNOUS Imaging, Inc.
InventorNico Dosenbach
Life of this patent
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Abstract
A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.
Claims24
A method of performing functional mapping of a subject for interventional planning, comprising:
- using a computer system, acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject;
- using a computer system, determining functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data;
- identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity;
- and
- using a computer system, generating a report indicating the target location.
A system comprising:
- a computing device including a processor programmed to:
- receive functional magnetic resonance imaging (fMRI) data of a brain of the subject;
- determine functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data;
- identify a target location in the brain to be targeted by neuromodulation based on the determined functional connectivity;
- and
- a display configured to display the target location.
A system, comprising:
- a computing device including a processor electrically coupled to a memory, the processor programmed to:
- acquire resting-state functional magnetic resonance imaging (rs-fMRI) data of a brain of the subject;
- determine functional connectivity between separate regions of the brain by assessing low-frequency changes in blood oxygenation level dependent (BOLD) signals from the rs-fMRI data by comparing the rs-fMRI data to a predetermined threshold;
- and
- generate a map of functional connectivity of the brain at least showing areas of the brain with low-frequency changes in the BOLD signals below the predetermined threshold;
- and
- a display to display the map of functional connectivity.
Dependencies are inferred from the claim text.